Paracetamol infusion








Introduction


Paracetamol has analgesic and antipyretic effects similar to those of aspirin. However, it has no anti-inflammatory effect and does not share the antirheumatic properties of the salicylates. It is rapidly and practically completely absorbed from the gastro-intestinal tract. The concentration in plasma reaches a peak in 30 to 60 minutes and the plasma half-life is about 2 hours after therapeutic doses. It is distributed into most body tissues.


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Indications


For the relief of mild to moderate pain and fever.


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Dosage and Administration


Adolescents and adults weighing more than 50 kg:


Paracetamol 1g per administration, i.e. one 100 ml vial, up to four times a day


The minimum interval between each administration must be 4 hours


The maximum daily dose must not exceed 4g


Children weighing more than 33 kg (approximately 11 years old), adolescents and adults weighing less than 50kg:


Paracetamol 15mg/kg per administration, i.e. 1.5ml solution per kg up to four times a day


The minimum interval between each administration must be 4 hours


The maximum daily dose must not exceed 60 mg/kg (without exceeding 3g)


Children weighing more than 10kg (approximately 1 year old) and weighing


less than 33kg:


Paracetamol 15mg/kg per administration, i.e. 1.5ml solution per kg up to four times a day


The minimum interval between each administration must be 4 hours


The maximum daily dose must not exceed 60mg/kg (without exceeding 2g)


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CONTRA-INDICATIONS:


Sensitivity to paracetamol.


Severe liver function impairment.


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WARNING:


Dosage in excess of those recommended may cause severe liver damage. Patients suffering from liver or kidney disease should only take paracetamol under medical supervision. Consult your doctor if no relief is obtained from the recommended dosage.





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